My favorite application launcher Launchy just released a new version 2.0 two days ago. Are you tired of starting applications by going to the Start menu or clicking on the desktop or Quick Launch icons? If you would like to start applications with only your keyboard, use Launchy. I wrote about it sometimes ago. It's free, fast and has an elegant interface, so try it today!
Disclaimer: This is not an ad although it sounds like one. I just think that it rocks :P
And, 2.0 supports Windows Vista, in case you have a pretty new machine :)